The Cleopatra IV Cocktail Istanbul | Skin Radiance Support

What is the Cleopatra IV Cocktail?

It is the intravenous administration of vitamin C, antioxidants and minerals involved in skin health. The aim is to support the skin’s moisture balance and antioxidant defence from within — to bring vitality back to skin that looks tired and dull. Sessions at IV Point take 45–60 minutes and follow a physician assessment.

Why Does Skin Look Dull and Tired?

A vital-looking skin doesn’t depend on one thing. Several factors work together:

Moisture balance. Fluid loss changes the skin’s plumpness and the way it reflects light; this is the most quickly noticed cause of a dull look.
Antioxidant status. Sun, smoking, air pollution and stress increase oxidative load. Healthy skin contains vitamin C at high concentrations, and this contributes to antioxidant protection against UV-related photodamage.¹
Collagen production. Vitamin C is one of the essential cofactors stimulating collagen synthesis.¹ Collagen determines the skin’s firmness and elasticity.
Sleep, diet and circulation. Your skin’s appearance mirrors your general condition.

The Cleopatra IV Cocktail targets the nutritional and antioxidant side of this picture. It is not a skin treatment; it is a treatment that supports your skincare routine from within.

“Radiance” and “Whitening” Are Not the Same Thing

We want to make this distinction clear, because the two are often confused — and there is a great deal of exaggeration in the market.

Radiance and vitality are about the skin’s moisture balance, barrier function, antioxidant status and circulation. Skin that looks tired, dull and flat can look more vital and fresh through these channels. That is what our treatment aims at.

Whitening means lightening the skin’s colour by reducing melanin production. That is an entirely different mechanism, and there is insufficient data showing that intravenous glutathione produces this effect.² We therefore do not offer any treatment aimed at lightening skin colour or removing spots, and we promise no such result.

In short: we can support your skin in looking more vital and fresh. We do not aim to lighten your skin’s colour.

If pigmentation spots bother you, the right address is a dermatology assessment. Melasma, sun spots and post-inflammatory hyperpigmentation are different conditions, each with its own treatments of proven effectiveness.

About the Formula

The treatment is planned individually after the pre-treatment assessment. Core components:

Vitamin C: the protocol’s main component — for its cofactor role in collagen synthesis and its antioxidant effect¹
B-vitamin complex (including biotin): cofactors in the cell renewal of skin, hair and nail tissue
Zinc: for its role in wound healing and skin integrity
Amino acids used in collagen synthesis (lysine, arginine, proline): building blocks involved in assembling and cross-linking the collagen structure
Fluid and electrolyte support: sterile isotonic sodium chloride solution, to contribute to the skin’s moisture balance

The formula is not fixed; it is set by the physician according to your skin condition, health history and medications.

Why aren’t doses listed here?

Doses are set individually; we do not publish a standard dosing chart on the website. The contents and doses to be used are explained to you in detail before the session.

Potential Benefits

Support for skin vitality and freshness — through moisture balance and antioxidant support
Support for nutrients involved in collagen production — through vitamin C, zinc and amino acids (lysine, arginine, proline)
A contribution to antioxidant defence — during periods of increased oxidative load
Cofactor support for skin, hair and nails — through B vitamins and zinc

Effects vary from person to person. This treatment does not treat pigmentation spots, does not lighten skin colour, does not remove wrinkles, and does not replace dermatological treatment.

Who Might Consider This Supportive Treatment?

Adults whose skin looks dull, tired and flat, and who want support from within
People wanting to restore their skin’s vitality after an intense period, a long flight or heavy travel
People with factors that increase oxidative load, such as smoking or long-term sun exposure
People wanting general support before a special event
People wanting to support their skincare routine from within

Who Is It Not Suitable For?

Kidney failure
Pregnancy and breastfeeding
Heart failure and serious heart disease — because of the risk of fluid overload
Iron-overload diseases (hemochromatosis, thalassemia) — vitamin C increases iron absorption
Anyone receiving chemotherapy or radiotherapy — the effect of high-dose antioxidants on treatment effectiveness is debated; not administered without your oncologist’s approval
Known allergy to any component
An undiagnosed or changing skin lesion — dermatological assessment comes first

Tell us about every medication you use before the treatment.

Possible Side Effects

Temporary redness, tenderness or bruising at the IV site
Nausea or dizziness with a fast infusion
Allergic reaction to a component (rare)

Equipment to respond to a possible allergic reaction is kept ready, and the treatment is carried out under the supervision of an anesthesiology specialist.

Before, During and After

Before: no need to fast. Tell us about your medications and chronic conditions.

During: 45–60 minutes. You can rest seated, work or listen to music.

After: no particular restrictions. For your skin’s moisture balance, we recommend keeping up your water intake through the day.

See a Dermatologist If You Notice These Skin Changes

Some lesions mistaken for pigmentation spots need a different kind of assessment. If a mole or spot shows any of the following, it is worth having a dermatologist look at it:

Asymmetry — the two halves of the lesion don’t match
Border irregularity — ragged or blurred edges
Colour variation — more than one shade (brown, black, red, white, blue)
Diameter — larger than 6 millimetres
Evolution — change in size, colour, shape or elevation

A lesion that bleeds, itches or doesn’t heal; a new dark line under a nail; a new, fast-growing spot — these should be assessed the same way. Caught early, treatment success is high.

References

Pullar JM, Carr AC, Vissers MCM. The Roles of Vitamin C in Skin Health. Nutrients. 2017;9(8):866. pubmed.ncbi.nlm.nih.gov/28805671
Sonthalia S, Daulatabad D, Sarkar R. Glutathione as a skin whitening agent: Facts, myths, evidence and controversies. Indian Journal of Dermatology, Venereology and Leprology. 2016;82(3):262-272. pubmed.ncbi.nlm.nih.gov/27088927
Davids LM, van Wyk JC, Khumalo NP. Intravenous glutathione for skin lightening: Inadequate safety data. South African Medical Journal. 2016;106(8):782-786. pubmed.ncbi.nlm.nih.gov/27499402
Alzahrani TF, et al. Exploring the Safety and Efficacy of Glutathione Supplementation for Skin Lightening: A Narrative Review. Cureus. 2025;17(1):e78045. pubmed.ncbi.nlm.nih.gov/40013212

Written and medically reviewed by: Ömer Fatih Şahin, MD Specialist in Anesthesiology & Reanimation — Last updated: 27.08.2026

The content on this page is for informational purposes only and is not a substitute for medical treatment. The treatment is administered to individuals found suitable at a pre-treatment assessment. For pigmentation spots, moles and other skin complaints, please see a dermatology specialist.

Frequently Asked Questions

Will my skin look brighter?

That is what we aim for: skin that looks more vital and fresh, through moisture balance and antioxidant support. But this has nothing to do with lightening the skin's colour, and the effect varies from person to person.

Will it whiten my skin?

No. We do not administer treatments aimed at lightening skin colour. There is insufficient data proving a skin-lightening effect of intravenous glutathione,² while the literature contains reports of serious adverse effects.^3,4 That is why we do not offer such a service.

Will it remove my pigmentation spots?

No. Melasma, sun spots and other hyperpigmentation conditions have different causes, and each has its own treatment. The right address is a dermatology assessment.

Will it reduce my wrinkles?

We make no such promise. Vitamin C is involved in collagen synthesis,¹ but that does not mean externally administered vitamin C reduces wrinkles.

How soon will I see an effect?

A feeling of freshness linked to fluid support can be noticed relatively quickly. The antioxidant and collagen side does not produce a visible change in a short time. We do not promise a visible skin transformation.

How often can I have it?

We do not propose a fixed course program. Frequency is decided at the assessment, based on your skin condition and general health.

How is it different from taking vitamin C by mouth?

Given intravenously, the digestive step is skipped and blood levels rise beyond what oral intake can reach. But this has not been shown to create a measurable advantage for skin health; the current review notes that supplementation's effectiveness is poorly understood compared with optimizing dietary intake.¹

What else should I do for my skin?

The foundation of skin health is: regular sunscreen use, stopping smoking, adequate sleep, a balanced diet and the topical treatments your dermatologist recommends. This treatment is a support added on top of that foundation; it does not replace it.

Does it hurt?

Only a mild sting as the IV line is placed. If you have a fear of needles, a thinner cannula and topical anesthetic cream can be used.

Related pages: Anti-Aging IV Therapy · High-Dose Vitamin C IV Therapy